Can I assume that you are working with one of our -S modules, running Digi's plug and play firmware?
Asusming this is the case, you will likely want to have the serial port's profile configured for TCP Sockets and further configure the profile to be either a TCP server or client (depending on your desired behavior).
He is a quick and dirty setup you can use to obtain some confirmation that something is working.
1. Configure the serial profile for TCP Sockets. By default the Telnet port will be set for 2100, Raw 2101 and SSL 2601.
2. Configure the serial port's basic setting, i.e. baud rate, data bits, etc., appropriately.
3. Use telnet and connect to the ME, using port 2100.
4. Connect your terminal emulation package o serial port 1, of the provided development board. Setting up the package's serial setting to match those of the Connect ME.
5. At this point you should be able to send data (e.g. key strokes) from one application to the other, and vise-versa.
It should certainly be that simple.