Hello,
Are you saying that you have 5 identical USB devices (Pico USB TC-08) attached to the AnywhereUSB/5 G2? If so, does the problem "follow" USB port #5 or does it "follow" a certain USB device? To determine this, connect a known working USB device (say, that was on USB port 1) and connect it to USB port 5 and let us know the result.