It does not really matter the total number of node so much as it is the total amount of data being sent. As long as you do not exceed the streaming limit of 80kbps, you should be fine. With that said, if a data collision occurs, automatic retries should kick in. Otherwise you should get a response in the API status frame indicating if it was received or not. If it was not received, you may want to re-transmit the packet. But that is dependent on your software protocol if that is necessary or not.