Have you confirmed there are no firewall/antivirus applications blocking the connectivity ports?
http://knowledge.digi.com/articles/Knowledge_Base_Article/How-to-configure-Windows-Firewall-to-allow-an-AnywhereUSB-to-connect-to-a-host-computer
http://knowledge.digi.com/articles/Knowledge_Base_Article/No-Remote-Hubs-found-message-in-the-AnywhereUSB-Configuration-Utility
http://knowledge.digi.com/articles/Knowledge_Base_Article/Connecting-to-this-computer-status-in-AnywhereUSB-Configuration-Utility