Hi CraigC,
To answer your question, we don't test the AnywhereUSB Manager software in any particular Virtual Machine software or other, since your AnywhereUSB Manager software is only tested with the various Operating System environments its designed to run in, as listed here on the product's specifications page:
https://www.digi.com/products/networking/infrastructure-management/usb-connectivity/usb-over-ip/anywhereusb#specifications
That being said, those Operating Systems typically run on top of your Virtual Machine environment, so as long as all other conditions are met to run the Operating System in your Virtual Machine, the AnywhereUSB Manager software should install into the supported Operating Systems on that list without issue.
If issues are encountered however, you'll want to contact Technical Support after registering your product at the following link as your next step:
https://www.digi.com/support/warranty