1. Unplug the USB cable from the Edgeport.
2. Download a special version of the Edgeport Configuration Utility here
3. Run the file (from #2), click the Advanced tab, click the Uninstall button and reboot the computer when prompted.
4. After Windows loads, you should be able to install the Edgeport without getting the "IonMultiPortSerial" error message.
If problem persists after following the guidance above, please contact Digi Technical Support
May 24, 2019